The results suggest that the extent of the benzodiazepines' amnesic effects-both negative (anterograde) and positive (retrograde)-depends on the dosage and type of substance. the benzodiazepines had not negative retrograde amnestic effects, but rather "promnesic" effects. Performance in the memory tests was better under benzodiazepines than under placebo as regards material learned before drug ingestion, i.e. Results after 1 mg lormetazepam did not differ from those after placebo. Lormetazepam 2 mg produced less marked impairments than flunitrazepam. The greatest anterograde memory impairments were observed after 2 mg flunitrazepam (p less than 0.05). A distinction must be made between anterograde amnesic effects and retrograde amnesic effects. Recognition was also tested after 24 h for all five versions.
The target variables were immediate recall (after presentation and a 10-s distraction task) and delayed recall and recognition (after 30 min). Different test versions were used on each occasion. Tests were performed before drug ingestion, and 1, 2, 3, and 5 h after application. The tests consisted of word lists, picture tests, and syllable pairs (consonant-vowel-consonant trigrams).
Four independent groups of 10 subjects randomly received either 1 mg lormetazepam, 2 mg lormetazepam, 2 mg flunitrazepam, or placebo. However, amnesia is far more complicated and severe than everyday forgetfulness. Amnesia, in the Greek language, means forgetfulness. The study was designed as a double-blind and placebo-controlled trial. If you have amnesia you may be unable to recall past information (retrograde amnesia) and/or hold onto new information (anterograde amnesia). In a pharmacopsychological study, memory impairments after single oral doses of benzodiazepines or placebo were investigated in 40 healthy men aged 20-40 years.
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